An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

Is Iran threatened by Zika virus?

Zika virus is an Arbovirus identified first time in 1947 in Uganda. Zika epidemic is a threat far greater than the Ebola outbreak. The World Health Organization has urged Asian countries to be vigilant about the risk of spreading Zika virus and preventive measures to control it. In Iran, 64 species of mosquitoes from Culicidea family have been reported three of which belong to the Aedes genus, ...

Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus

The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains ...

Plant‐produced Zika virus envelope protein elicits neutralizing immune responses that correlate with protective immunity against Zika virus in mice

The global Zika virus (ZIKV) outbreak and its link to foetal and newborn microcephaly and severe neurological complications in adults call for the urgent development of ZIKV vaccines. In response, we developed a subunit vaccine based on the ZIKV envelope (E) protein and investigated its immunogenicity in mice. Transient expression of ZIKV E (zE) resulted in its rapid accumulation in leaves of N...

Studies on the responses of calves to an attenuated rinderpest vaccine Virus

Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo.

Single-stranded RNA stimulates immune cells and induces the secretion of pro-inflammatory cytokines and type I IFN. As adjuvant RNA can induce a T(h)2 type of humoral response, however, its potency in the induction of cytotoxic T cells in vivo has not been analyzed. Here we show that immunization with the antigen ovalbumin (OVA) and the adjuvant phosphodiester RNA complexed to the cationic lipi...